Sakamakon binciken ya nuna cewa mazan da suka karbi allurar testosterone undecanoate na dogon lokaci sun fi dacewa da jiyya bayan shekara 1 fiye da mazan da suka karbi gajeren lokaci na testosterone propionate injections.
Wani bincike na baya-bayan nan na bayanai daga fiye da 122,000 maza a Amurka ya nuna cewa maza da aka bi da su tare da testosterone undecanoate (Aveed, Endo Pharmaceuticals) suna da irin wannan ma'auni a cikin watanni 6 na farko na jiyya kamar yadda maza suka bi da testosterone cypionate.Yawan biyan kuɗi ya kasance daga 7 zuwa watanni 12, tare da kawai 8.2% na marasa lafiya da aka bi da su tare da testosterone cypionate ci gaba da jiyya don watanni 12 idan aka kwatanta da 41.9% na marasa lafiya da aka bi da su tare da testosterone undecanoate.
"Shaidun sun nuna cewa mafi dacewa nau'i na maganin testosterone, irin su injections na dogon lokaci, suna da mahimmanci ga shirye-shiryen maza tare da rashi na testosterone don ci gaba da jiyya," in ji Abraham Morgenthaler, MD, mataimakin farfesa na tiyata.Helio ya ce ya yi aiki a sashen urology a Cibiyar Kiwon Lafiya ta Beth Israel Deaconess a Makarantar Kiwon Lafiya ta Harvard."Akwai haɓaka fahimtar cewa ƙarancin testosterone wani muhimmin yanayin kiwon lafiya ne kuma maganin testosterone na iya inganta ba kawai bayyanar cututtuka ba har ma da fa'idodin kiwon lafiya gabaɗaya kamar ingantaccen sarrafa sukari na jini, rage yawan kitse da ƙara yawan ƙwayar tsoka, yanayi, ƙasusuwa masu yawa da kuma dalilin da ba a bayyana ba. .anemia.Duk da haka, waɗannan fa'idodin za a iya samun su ne kawai idan maza suka tsaya kan magani.
Morgenthaler da abokan aiki sun gudanar da bincike na baya-bayan nan game da bayanai daga bayanan Veradigm, wanda ya ƙunshi bayanan rikodin lafiyar lantarki daga wuraren jinya na Amurka, ciki har da waɗanda suka fara injectable testosterone undecanoate ko testosterone cypionate tsakanin 2014 da 2018. Maza masu shekaru 18 da sama.Bayanan da aka tattara a cikin haɓakar watanni 6 kamar na Yuli 2019. An bayyana farfadowar kulawa a matsayin tazara tsakanin alƙawura wanda bai wuce sau biyu na shawarar da aka ba da shawarar ba na 20 makonni don testosterone undecanoate ko 4 makonni don testosterone cypionate.An ƙididdige ma'amalar jiyya daga ranar allurar farko zuwa ranar dakatarwa, canjin takardar sayan magani, ko ƙarshen asalin maganin testosterone.Testosterone ba a yarda da shi ba a cikin ƙungiyar testosterone undecanoate an bayyana shi azaman rata fiye da kwanaki 42 tsakanin ƙarshen kwanan wata na farko da ranar farawa na alƙawari na biyu, ko rata fiye da kwanaki 105 tsakanin alƙawura na gaba.Rashin daidaituwa a cikin ƙungiyar cypionate testosterone an bayyana shi azaman tazara fiye da kwanaki 21 tsakanin ƙarshen alƙawari ɗaya da farkon na gaba.Masu binciken sun tantance canje-canje a cikin nauyin jiki, BMI, hawan jini, matakan testosterone, adadin sababbin abubuwan da ke faruwa na zuciya da jijiyoyin jini, da abubuwan haɗari daga watanni 3 kafin allurar farko zuwa watanni 12 bayan fara magani.
Ƙungiyar binciken ta ƙunshi maza 948 da ke shan testosterone undecanoate da 121,852 maza suna shan cypionate testosterone.A asali, 18.9% na maza a cikin ƙungiyar testosterone undecanoate da 41.2% na maza a cikin ƙungiyar cypionate testosterone ba su da ganewar asali na hypogonadism.Ma'anar testosterone kyauta a asali ya kasance mafi girma a cikin marasa lafiya da ke shan testosterone undecanoate idan aka kwatanta da wadanda ke shan cypionate testosterone (65.2 pg / mL vs 38.8 pg / mL; P <0.001).
A cikin watanni 6 na farko, ƙimar ma'amala sun kasance iri ɗaya a cikin ƙungiyoyin biyu.A cikin tsawon watanni 7 zuwa 12, ƙungiyar testosterone undecanoate tana da matsayi mafi girma fiye da ƙungiyar cypionate testosterone (82% vs 40.8%; P <0.001).Idan aka kwatanta da watanni 12, yawancin maza a cikin ƙungiyar undecanoate na testosterone sun ci gaba da maganin kwayoyin testosterone (41.9% vs 0.89.9%; P <0.001).Maza suna shan testosterone cypionate.
"Abin mamaki ne, kawai 8.2 bisa dari na maza da suka allurar cypionate testosterone sun ci gaba da jiyya bayan shekara 1," in ji Morgenthaler."Mafi ƙarancin ƙimar maganin testosterone da aka fi amfani da shi a cikin Amurka yana nufin cewa ba a kula da maza masu ƙarancin testosterone."
Marasa lafiya da aka bi da su tare da testosterone undecanoate suna da babban ma'ana canje-canje a cikin jimlar testosterone (171.7 ng / dl vs 59.6 ng / dl; P <0.001) da testosterone kyauta (25.4 pg / ml vs 3.7 pg / ml; P = 0.001).Ƙara yawan watanni 12 idan aka kwatanta da marasa lafiya da aka bi da su tare da testosterone cypionate.Testosterone undecanoate ya nuna rashin daidaituwa a cikin jimlar matakan testosterone fiye da testosterone cypionate.
A watanni 12, ma'anar canje-canje a cikin nauyi, BMI, da hawan jini sun kasance daidai tsakanin kungiyoyi.Ƙungiyar testosterone undecanoate tana da mafi girma na maza tare da sababbin cututtukan da aka gano a cikin maza da kuma kiba a biyo baya, yayin da ƙungiyar cypionate testosterone ta sami mafi girma na maza da aka gano tare da hauhawar jini, ciwon zuciya, da ciwo mai tsanani.
Ana buƙatar ƙarin bincike don fahimtar dalilin da yasa yawancin maza da ke allurar testosterone cypionate suna dakatar da jiyya a cikin shekara guda, in ji Morgenthaler.
"Zamu iya ɗauka cewa a cikin wannan binciken, an yi amfani da testosterone undecanoate a cikin adadi mai yawa na watanni 12 saboda dacewa da maganin da aka dade, amma don ganin ko wannan zai iya zama saboda wasu dalilai (kamar farashi), ƙiyayya ga akai-akai allurar rigakafin kai, rashin ingantaccen ci gaba a cikin alamun bayyanar cututtuka, ko wasu dalilai, ”in ji Morgenthaler.
Lokacin aikawa: Jul-05-2023