Magunguna guda biyar don maganin asarar nauyi a cikin manya marasa lafiya tare da kiba na farko-Semaglutide.

I. Bayanan asali
Generic Name: Semaglutide
Nau'in: GLP-1 agonist mai karɓa (analog na glucagon-kamar peptide-1 mai tsayi)
Tsarin Gudanarwa na yau da kullun: Allurar subcutaneous (sau ɗaya kowane mako)

II. Alamu da Matsayin Yarda da Gida
Alamun da aka amince
Nau'in Maganin Ciwon Suga Na 2 (NMPA Ta Amince):
Sashi: 0.5 MG ko 1.0 MG, sau ɗaya a mako.

Ayyuka: Yana daidaita glucose na jini kuma yana rage haɗarin bugun jini.

Maganin Kiba/Kiba

III. Tsarin Ayyuka da Ingantattun Ayyuka
Core Mechanism: Yana kunna masu karɓar GLP-1, yana jinkirta zubar da ciki, kuma yana ƙaruwa.

Yana aiki akan cibiyar ci abinci na hypothalamic, yana hana ci.

Yana inganta haɓakar insulin kuma yana daidaita metabolism.

Tasirin Rage Nauyi (Bisa ga gwaji na asibiti na duniya):
Matsakaicin asarar nauyi sama da makonni 68: 15% -20% (a hade tare da ayyukan rayuwa).

Marasa lafiya marasa ciwon sukari (BMI ≥ 30 ko ≥ 27 tare da rikitarwa):

Marasa lafiya masu ciwon sukari: Tasirin asarar nauyi kaɗan kaɗan (kimanin 5% -10%).

IV. m Yawan jama'a da kuma Contraindications
Yawan Jama'a
Matsayin Duniya (koma ga WHO):
BMI ≥ 30 (kiba);
BMI ≥ 27 tare da hauhawar jini, ciwon sukari, ko wasu cututtuka na rayuwa (kiba).

Ayyukan Gida: Yana buƙatar kimantawar likita; A halin yanzu ana amfani da shi don sarrafa nauyi a cikin marasa lafiya masu ciwon sukari.

Contraindications
Tarihin sirri ko iyali na medullary thyroid carcinoma (MTC);
Nau'in ciwon neoplasia na endocrine da yawa (MEN2);
Mata masu ciki ko masu shayarwa;
Ciwon ciki mai tsanani (kamar tarihin pancreatitis).

V. Side Effects and Risks
Illolin gama gari (haɗuwa> 10%):
tashin zuciya, amai, zawo, maƙarƙashiya (raguwa tare da dogon amfani).

Rage cin abinci, gajiya.

Mummunan Hatsari:

Ciwon daji na C-cell (hadarin da aka nuna a nazarin dabba, ba a bayyana a cikin mutane ba tukuna);
pancreatitis, cutar gallbladder;
Hypoglycemia (tsanaki da ake buƙata lokacin amfani da shi tare da sauran wakilai na hypoglycemic).

VI. Amfani na yanzu a China

Hanyoyin Samun:
Maganin Ciwon Suga: Takardun magani daga asibiti na yau da kullun.
Maganin Rage Nauyi: Yana buƙatar cikakken kimantawa daga likita; Wasu sassan asibitocin endocrinology na iya rubuta shi.

Hatsari daga Tashoshi marasa hukuma: Magungunan da aka siya ta hanyoyin da ba na hukuma ba na iya zama jabu ko ba a adana su da kyau ba, suna haifar da haɗari.

VII. Shawarwari na Amfani

Bi umarnin Likita sosai: Yi amfani da shi kawai bayan likita ya tantance alamun rayuwa da tarihin likitancin iyali.

Haɗin Salon Rayuwa: Ana buƙatar magani tare da sarrafa abinci da motsa jiki don cimma sakamako mafi kyau.

Kulawa na Tsawon Lokaci: Kula da aikin thyroid akai-akai, enzymes pancreatic, da aikin hanta da koda.